[Neurological damage linked to coronaviruses : SARS-CoV-2 and other human coronaviruses].
Identifieur interne : 000069 ( Main/Exploration ); précédent : 000068; suivant : 000070[Neurological damage linked to coronaviruses : SARS-CoV-2 and other human coronaviruses].
Auteurs : Sara Salinas [France] ; Yannick Simonin [France]Source :
- Medecine sciences : M/S [ 1958-5381 ]
Descripteurs français
- KwdFr :
- Animaux (MeSH), Betacoronavirus (pathogénicité), Coronaviridae (pathogénicité), Coronaviridae (physiologie), Coronaviridae (ultrastructure), Humains (MeSH), Infections à Coronaviridae (complications), Infections à coronavirus (complications), Infections à coronavirus (diagnostic), Infections à coronavirus (physiopathologie), Infections à coronavirus (traitement médicamenteux), Maladies du système nerveux (diagnostic), Maladies du système nerveux (thérapie), Maladies du système nerveux (virologie), Maladies du système nerveux (étiologie), Maladies transmissibles émergentes (MeSH), Pandémies (MeSH), Pneumopathie virale (complications), Pneumopathie virale (diagnostic), Pneumopathie virale (physiopathologie), Réplication virale (MeSH), Spécificité d'organe (MeSH), Système nerveux (virologie), Techniques de laboratoire clinique (MeSH), Transport biologique (MeSH), Tropisme viral (MeSH), Virulence (MeSH), Zoonoses (MeSH).
- MESH :
- diagnostic : Infections à coronavirus, Maladies du système nerveux, Pneumopathie virale.
- pathogénicité : Betacoronavirus, Coronaviridae.
- physiologie : Coronaviridae.
- physiopathologie : Infections à coronavirus, Pneumopathie virale.
- thérapie : Maladies du système nerveux.
- traitement médicamenteux : Infections à coronavirus.
- virologie : Maladies du système nerveux, Système nerveux.
- étiologie : Coronaviridae, Maladies du système nerveux.
- complications : Animaux, Humains, Infections à Coronaviridae, Infections à coronavirus, Maladies transmissibles émergentes, Pandémies, Pneumopathie virale, Réplication virale, Spécificité d'organe, Techniques de laboratoire clinique, Transport biologique, Tropisme viral, Virulence, Zoonoses.
English descriptors
- KwdEn :
- Animals (MeSH), Betacoronavirus (pathogenicity), Biological Transport (MeSH), Clinical Laboratory Techniques (MeSH), Communicable Diseases, Emerging (MeSH), Coronaviridae (pathogenicity), Coronaviridae (physiology), Coronaviridae (ultrastructure), Coronaviridae Infections (complications), Coronavirus Infections (complications), Coronavirus Infections (diagnosis), Coronavirus Infections (drug therapy), Coronavirus Infections (physiopathology), Humans (MeSH), Nervous System (virology), Nervous System Diseases (diagnosis), Nervous System Diseases (etiology), Nervous System Diseases (therapy), Nervous System Diseases (virology), Organ Specificity (MeSH), Pandemics (MeSH), Pneumonia, Viral (complications), Pneumonia, Viral (diagnosis), Pneumonia, Viral (physiopathology), Viral Tropism (MeSH), Virulence (MeSH), Virus Replication (MeSH), Zoonoses (MeSH).
- MESH :
- complications : Coronaviridae Infections, Coronavirus Infections, Pneumonia, Viral.
- diagnosis : Coronavirus Infections, Nervous System Diseases, Pneumonia, Viral.
- drug therapy : Coronavirus Infections.
- etiology : Nervous System Diseases.
- pathogenicity : Betacoronavirus, Coronaviridae.
- physiology : Coronaviridae.
- physiopathology : Coronavirus Infections, Pneumonia, Viral.
- therapy : Nervous System Diseases.
- ultrastructure : Coronaviridae.
- virology : Nervous System, Nervous System Diseases.
- Animals, Biological Transport, Clinical Laboratory Techniques, Communicable Diseases, Emerging, Humans, Organ Specificity, Pandemics, Viral Tropism, Virulence, Virus Replication, Zoonoses.
Abstract
The recent emergence of a new coronavirus, SARS-CoV-2, responsible for COVID-19, is a new warning of the risk to public health represented by viral zoonoses and in particular by coronaviruses. Mainly described as being able to infect the upper and lower respiratory tract, coronaviruses can also infect the central and peripheral nervous systems as many other respiratory viruses, such as influenza or respiratory syncytial virus. Viral infections of the nervous system are a major public health concern as they can cause devastating illnesses up to death, especially when they occur in the elderly, who are more susceptible to these infections. Knowledge concerning the pathophysiology of recently emerging coronaviruses (MERS-CoV, SARS-CoV and SARS-CoV-2) and how they reach the central nervous system are very sketchy and the work in progress aims in particular to better understand their biology and the mechanisms associated with neurological damage. In this review we will discuss the current state of knowledge on the neurotropism of human coronaviruses and the associated mechanisms by developing in particular the latest data concerning SARS-CoV-2.
Title
Les atteintes neurologiques liées au SARS-CoV-2 et autres coronavirus humains.
Abstract
L’émergence récente d’un nouveau coronavirus, le SARS-CoV-2, responsable de la maladie appelée COVID-19, est un nouvel avertissement du risque pour la santé publique représenté par les zoonoses virales et notamment par les coronavirus. Principalement connus pour leur capacité à infecter les voies respiratoires supérieures et inférieures, les coronavirus peuvent également affecter le système nerveux central et périphérique, comme c’est le cas pour de nombreux virus respiratoires, tels que les virus influenza ou le virus respiratoire syncytial. Les infections du système nerveux sont un problème important de santé publique car elles peuvent provoquer des atteintes dévastatrices allant jusqu’au décès du patient, en particulier lorsqu’elles surviennent chez les personnes fragilisées ou âgées plus sensibles à ce type d’infection. Les connaissances de la physiopathologie des infections par les coronavirus émergents (MERS-CoV, SARS-CoV et SARS-CoV-2) et leurs moyens d’accéder au système nerveux central sont, pour l’heure, très sommaires. Les travaux en cours visent notamment à mieux appréhender les mécanismes associés aux atteintes neurologiques observées. Dans cette revue nous aborderons l’état des connaissances actuelles sur le neurotropisme des coronavirus humains et les mécanismes associés en développant tout particulièrement les dernières données concernant le SARS-CoV-2.
DOI: 10.1051/medsci/2020122
PubMed: 32755537
Affiliations:
Links toward previous steps (curation, corpus...)
Le document en format XML
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d'organe</term><term>Techniques de laboratoire clinique</term><term>Transport biologique</term><term>Tropisme viral</term><term>Virulence</term><term>Zoonoses</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The recent emergence of a new coronavirus, SARS-CoV-2, responsible for COVID-19, is a new warning of the risk to public health represented by viral zoonoses and in particular by coronaviruses. Mainly described as being able to infect the upper and lower respiratory tract, coronaviruses can also infect the central and peripheral nervous systems as many other respiratory viruses, such as influenza or respiratory syncytial virus. Viral infections of the nervous system are a major public health concern as they can cause devastating illnesses up to death, especially when they occur in the elderly, who are more susceptible to these infections. Knowledge concerning the pathophysiology of recently emerging coronaviruses (MERS-CoV, SARS-CoV and SARS-CoV-2) and how they reach the central nervous system are very sketchy and the work in progress aims in particular to better understand their biology and the mechanisms associated with neurological damage. In this review we will discuss the current state of knowledge on the neurotropism of human coronaviruses and the associated mechanisms by developing in particular the latest data concerning SARS-CoV-2.</div><div type="abstract" xml:lang="fr"><p><b>Title</b></p><p>Les atteintes neurologiques liées au SARS-CoV-2 et autres coronavirus humains.</p></div><div type="abstract" xml:lang="fr"><p><b>Abstract</b></p><p>L’émergence récente d’un nouveau coronavirus, le SARS-CoV-2, responsable de la maladie appelée COVID-19, est un nouvel avertissement du risque pour la santé publique représenté par les zoonoses virales et notamment par les coronavirus. Principalement connus pour leur capacité à infecter les voies respiratoires supérieures et inférieures, les coronavirus peuvent également affecter le système nerveux central et périphérique, comme c’est le cas pour de nombreux virus respiratoires, tels que les virus influenza ou le virus respiratoire syncytial. Les infections du système nerveux sont un problème important de santé publique car elles peuvent provoquer des atteintes dévastatrices allant jusqu’au décès du patient, en particulier lorsqu’elles surviennent chez les personnes fragilisées ou âgées plus sensibles à ce type d’infection. Les connaissances de la physiopathologie des infections par les coronavirus émergents (MERS-CoV, SARS-CoV et SARS-CoV-2) et leurs moyens d’accéder au système nerveux central sont, pour l’heure, très sommaires. Les travaux en cours visent notamment à mieux appréhender les mécanismes associés aux atteintes neurologiques observées. Dans cette revue nous aborderons l’état des connaissances actuelles sur le neurotropisme des coronavirus humains et les mécanismes associés en développant tout particulièrement les dernières données concernant le SARS-CoV-2.</p></div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">32755537</PMID><DateCompleted><Year>2020</Year><Month>08</Month><Day>28</Day></DateCompleted><DateRevised><Year>2020</Year><Month>08</Month><Day>28</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1958-5381</ISSN><JournalIssue CitedMedium="Internet"><Volume>36</Volume><Issue>8-9</Issue><PubDate><MedlineDate>2020 Aug-Sep</MedlineDate></PubDate></JournalIssue><Title>Medecine sciences : M/S</Title><ISOAbbreviation>Med Sci (Paris)</ISOAbbreviation></Journal><ArticleTitle>[Neurological damage linked to coronaviruses : SARS-CoV-2 and other human coronaviruses].</ArticleTitle><Pagination><MedlinePgn>775-782</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1051/medsci/2020122</ELocationID><Abstract><AbstractText>The recent emergence of a new coronavirus, SARS-CoV-2, responsible for COVID-19, is a new warning of the risk to public health represented by viral zoonoses and in particular by coronaviruses. Mainly described as being able to infect the upper and lower respiratory tract, coronaviruses can also infect the central and peripheral nervous systems as many other respiratory viruses, such as influenza or respiratory syncytial virus. Viral infections of the nervous system are a major public health concern as they can cause devastating illnesses up to death, especially when they occur in the elderly, who are more susceptible to these infections. Knowledge concerning the pathophysiology of recently emerging coronaviruses (MERS-CoV, SARS-CoV and SARS-CoV-2) and how they reach the central nervous system are very sketchy and the work in progress aims in particular to better understand their biology and the mechanisms associated with neurological damage. In this review we will discuss the current state of knowledge on the neurotropism of human coronaviruses and the associated mechanisms by developing in particular the latest data concerning SARS-CoV-2.</AbstractText><CopyrightInformation>© 2020 médecine/sciences – Inserm.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Salinas</LastName><ForeName>Sara</ForeName><Initials>S</Initials><Identifier Source="ORCID">0000-0003-4492-2093</Identifier><AffiliationInfo><Affiliation>Pathogenèse et contrôle des infections chroniques (PCCI), UMR 1058, université de Montpellier, Inserm, EFS, 60 rue de Navacelles, 34000 Montpellier, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Simonin</LastName><ForeName>Yannick</ForeName><Initials>Y</Initials><Identifier Source="ORCID">0000-0002-3475-1369</Identifier><AffiliationInfo><Affiliation>Pathogenèse et contrôle des infections chroniques (PCCI), UMR 1058, université de Montpellier, Inserm, EFS, 60 rue de Navacelles, 34000 Montpellier, France.</Affiliation></AffiliationInfo></Author></AuthorList><Language>fre</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><VernacularTitle>Les atteintes neurologiques liées au SARS-CoV-2 et autres coronavirus humains.</VernacularTitle><ArticleDate DateType="Electronic"><Year>2020</Year><Month>08</Month><Day>05</Day></ArticleDate></Article><MedlineJournalInfo><Country>France</Country><MedlineTA>Med Sci (Paris)</MedlineTA><NlmUniqueID>8710980</NlmUniqueID><ISSNLinking>0767-0974</ISSNLinking></MedlineJournalInfo><SupplMeshList><SupplMeshName Type="Disease" UI="C000657245">COVID-19</SupplMeshName><SupplMeshName Type="Protocol" UI="C000657964">COVID-19 diagnostic testing</SupplMeshName><SupplMeshName Type="Protocol" UI="C000705127">COVID-19 drug treatment</SupplMeshName><SupplMeshName Type="Organism" UI="C000656484">severe acute respiratory syndrome coronavirus 2</SupplMeshName></SupplMeshList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000073640" MajorTopicYN="N">Betacoronavirus</DescriptorName><QualifierName UI="Q000472" MajorTopicYN="Y">pathogenicity</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D001692" MajorTopicYN="N">Biological Transport</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D019411" MajorTopicYN="N">Clinical Laboratory Techniques</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D021821" MajorTopicYN="N">Communicable Diseases, Emerging</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D003332" MajorTopicYN="N">Coronaviridae</DescriptorName><QualifierName UI="Q000472" MajorTopicYN="N">pathogenicity</QualifierName><QualifierName UI="Q000502" MajorTopicYN="N">physiology</QualifierName><QualifierName UI="Q000648" MajorTopicYN="N">ultrastructure</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D003333" MajorTopicYN="N">Coronaviridae Infections</DescriptorName><QualifierName UI="Q000150" MajorTopicYN="N">complications</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D018352" MajorTopicYN="N">Coronavirus Infections</DescriptorName><QualifierName UI="Q000150" MajorTopicYN="Y">complications</QualifierName><QualifierName UI="Q000175" MajorTopicYN="N">diagnosis</QualifierName><QualifierName UI="Q000188" MajorTopicYN="N">drug therapy</QualifierName><QualifierName UI="Q000503" MajorTopicYN="N">physiopathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D009420" MajorTopicYN="N">Nervous System</DescriptorName><QualifierName UI="Q000821" MajorTopicYN="N">virology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D009422" MajorTopicYN="N">Nervous System Diseases</DescriptorName><QualifierName UI="Q000175" MajorTopicYN="N">diagnosis</QualifierName><QualifierName UI="Q000209" MajorTopicYN="Y">etiology</QualifierName><QualifierName UI="Q000628" MajorTopicYN="N">therapy</QualifierName><QualifierName UI="Q000821" MajorTopicYN="N">virology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D009928" MajorTopicYN="N">Organ Specificity</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D058873" MajorTopicYN="Y">Pandemics</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D011024" MajorTopicYN="N">Pneumonia, Viral</DescriptorName><QualifierName UI="Q000150" MajorTopicYN="Y">complications</QualifierName><QualifierName UI="Q000175" MajorTopicYN="N">diagnosis</QualifierName><QualifierName UI="Q000503" MajorTopicYN="N">physiopathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D056189" MajorTopicYN="N">Viral Tropism</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D014774" MajorTopicYN="N">Virulence</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D014779" MajorTopicYN="N">Virus Replication</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D015047" MajorTopicYN="N">Zoonoses</DescriptorName></MeshHeading></MeshHeadingList><OtherAbstract Type="Publisher" Language="fre"><AbstractText Label="Title" NlmCategory="UNASSIGNED">Les atteintes neurologiques liées au SARS-CoV-2 et autres coronavirus humains.</AbstractText><AbstractText Label="Abstract" NlmCategory="UNASSIGNED">L’émergence récente d’un nouveau coronavirus, le SARS-CoV-2, responsable de la maladie appelée COVID-19, est un nouvel avertissement du risque pour la santé publique représenté par les zoonoses virales et notamment par les coronavirus. Principalement connus pour leur capacité à infecter les voies respiratoires supérieures et inférieures, les coronavirus peuvent également affecter le système nerveux central et périphérique, comme c’est le cas pour de nombreux virus respiratoires, tels que les virus influenza ou le virus respiratoire syncytial. Les infections du système nerveux sont un problème important de santé publique car elles peuvent provoquer des atteintes dévastatrices allant jusqu’au décès du patient, en particulier lorsqu’elles surviennent chez les personnes fragilisées ou âgées plus sensibles à ce type d’infection. Les connaissances de la physiopathologie des infections par les coronavirus émergents (MERS-CoV, SARS-CoV et SARS-CoV-2) et leurs moyens d’accéder au système nerveux central sont, pour l’heure, très sommaires. Les travaux en cours visent notamment à mieux appréhender les mécanismes associés aux atteintes neurologiques observées. 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